Transsexual Medicine

Purpose: Traumatic rupture of the corpus cavernosum of the penis is rare and has been reported infrequently. We demonstrated the moderate frequency and most common etiologies of this condition. Materials and Methods: Between February 1990 and June 1993, 68 patients underwent a n emergency operation 3 hours to 4 days after penile fracture. Results: Among 32 patients who completed a questionnaire functional results were excellent except for 3 with penile curvature and pain during coitus who underwent surgery more than 48 hours after injury. Conclusions: Fracture of the penis is a common urological problem. In our series the most common cause was manipulation. To avoid serious complications immediate surgical intervention is recommended.

Transition for a transsexual person is essentially the process of changing one’s sex and this process may include any number of procedures which may not necessarily be medical ones (Serano 2016, p. 30). The process of transition is central to the transsexual experience because it defines the operative arena of transsexuality – it is what transsexuals do. In 1998, Jay Prosser, a female –to-male (FTM) transsexual author published his first book called Second Skins: The Body Narratives of Transsexuality in which he emphasized on the importance of transsexual narratives. In this book, Prosser looks at how transition is made sense of in transsexual narratives. He categorized five meanings of transition as they are inscribed in the narratives i.e. conceptual, ontological, narratological, historic-discursive and political. Using this same framework, one can read into other narratives of transsexuality. This paper utilizes Prosser’s theoretical scaffold to read into the transsexual narratives of the television series ‘Pose’. The series is created and produced by numerous talented individuals among who are transsexual producers like Janet Mock and Our Lady J. The cast is also primarily constituted of transsexual actors. Therefore, the series may be considered as an important and credible narrative text. ‘Pose’ follows the lives of its protagonists (many of who are transsexual women) as they navigate their lives within and outside of the ‘ball culture’ of 1980s New York. The narratives of the transsexual characters affirm Prosser’s arguments and conceptualization of transition as being a route to the transsexual subject’s identity and bodily integrity; that narratives on trans embodiment are important for shaping medical practices and discourse; that transsexual narratives on embodiment, accounts of transsexual experiences and transsexual identity patterns precede the construction of the transsexual subject through technology; that somatic transition is initiated by active transsexual subjectivity rather than by the medical establishment; and that transition is a complex open-ended process.

Accepting estrogen after a sex-confirming operation improves brain connections, a key to memory, learning and emotions in transsexual women. Estradiol strengthens connections between areas of the brain involved in fine motor skills, learning, emotions and sensory perception, according a study to be presented Monday at ENDO 2019, the Endocrine Society's annual meeting in New Orleans, La. This not only shows that trans-women have to maintain hormone therapy after surgery, but also highlights the deep link between hormones and brain connectivity.

The Trump administration is considering defining gender as a binary biological, immutable condition determined “biologically” at birth. According to this proposed policy, one is either “male” or “female.” No other categories would be allowed. This policy change is apparently directed at transgender citizens who would be classified according to their chromosomal “identity” at birth, rather than their pre-or post-operative gender re-assignment.

This essay is really two essays…two threads which entwine. They arise from two distinct motives.

One is the need as neuroscientists o begin to grasp the many implications of the striking discovery of the multifaceted functional role of the meninges, in particular as to how we already realize that a host of neuropsychiatric disorders can arise from the loss of functionality of the structures within those membranes.

This new finding from Finland will reverberate with increasing force in the coming years as it further clinches the key intersection of the neurological with the immunological, and will often as yet unimagined avenues for developing our awareness of how these two heretofore seemingly only tangentially related domains synergize so intimately.

Currently there is a critical situation whereby the Transgender Guidelines Organizations such as WPATH and the physicians working with them continue to either recommend or prescribe cyproterone with damages the tissues within the Meninges by causing a less than maximally malignant tumor growth, a meningioma, in the tissues within the meninges

The situation we cover in this essay is as follows:

Trans organizations and medical professionals foolishly and incorrectly believe that anti androgens are necessary aspect of Transition for the Trans Person

In the United States they use Spironolactone, but in Europe they realize it is toxic so they don’ t use it.  Instead they use Cyproterone, but in here we realize that it is toxic so we don’t use it . 

However many in the Us and elsewhere obtain various transition medications and hormones online…because they are less expensive and because they can’t debate endlessly with poorly educated physicians

It has been known for some time now that Cyproterone can and often does lead to a relatively benign cancerous growth in the Brains’ meninges…

More over, the takin go f cyproterone is known to be frequently accompanied by extreme cognitive/emotional disturbance.

There is some indication that stopping the cyproterone will result in a remission of the tumor, that is, no further growth of aberrant cells within the tissues of the meninges.

Very Recently European health agencies have stopped using it for some purposes and where it continues they insist now on regular MRI scans to make sure that the tumor’s are not growing and out of control.

However over the past few years, neuroscientists have realized that the meninges are not simply protective layers or membranes surrounding the brain, but contain within them a crucial system of lymphatic circulation vessels which are necessary to clear the fluids in the brain on a regular basis, in fact intensely every night.

They also realize that when these lymphatic drainage vessels are not working well…as in aging…the fluids in the brain tend to accumulate proteins such as amyloid which are associated with dementia and Alzheimers

When the meninges experience tumorous growth of dysfunctional cells within that of necessity will disrupt the vessels within them and disrupt the lymphatic clearance process which is part of our immune systems’ function. and so that has to impact on the assumption of Alzheimer’s and cognitive deficit causing proteins and other substances

Ceasing the dosage of cyproterone is like patching a hole in a dike once the flood waters have come in and damaged the homes and property within insofar as the proteins that were not cleared have been there and whatever damage they have done over the years to the cognitive function cells have already been done.

Thus taking of cyproterone can, depending on the person, cause a deterioration in cognitive function in less than a year that might otherwise build up over aging and lead to dementia only in later life

So this means that even if these tumors caused by Cyproterone are monitored (rather preposterously, in fact, with brain MRI) once they are found, even if the Cyproterone administration is ceased and the tumors stop growing, there is no telling how much damage to the underlying neurons and cognitive function cells has already been caused.

So that the taking of Cyproterone is a recipe for accelerated and irreversible cognitive decline and dementia

The Trans organizations such as WPATH are fully aware of this, and continue to recommend dispensing Cyproterone and do not even make any effort to warn Trans persons of the serious risks to their future well-being  and health.

WPATH Board confirming that sex (gender) reassignment, properly indicated and performed as provided by the Standards of Care, has proven to be beneficial and effective in the treatment of individuals with transsexualism, gender identity disorder, and/or gender dysphoria.

Professing Selves: Transsexuality and Same-Sex Desire in Contemporary Iran Afsaneh Najmabadi Durham, NC: Duke University Press, 2014. vii + 450 pp. Under guise of an ethnography of transsexuality in contemporary Iran, Afsaneh Najmabadi has written a nuanced ethnography of the transition of the Iranian state and public sphere from one type (jins) to another. Building on Joan Scott's (1986) observation that gender is a useful category for historical analysis, Naj-mabadi goes beyond showing that sex and sexuality are also useful categories for historical analysis to suggest that somatic-constitutional transformation can be as well. Interestingly, these are all better categories for analysis of the pre-and post-op (Islamic revolution) state of Iran than they are for comprehending a class of transsexual Iranians. This book is a nuanced study of the ways in which the most stigmatized and least conforming of Iran's citizens evade but also embody rigid binaries of sex and gender. But it is even more an analysis of how science, law, journalism, and eventually Shi'i fiqh (jurisprudence) used the subjectivities, bodies, and practices of gender of sexually fluid people to shape public discourses and state institutions. In contrast to approaches that impart too much sinister agency to the state or too much creative empowerment to the individual citizen, this account shows how ever more precise articulations of transsexuality in narratives, popular culture, state certification, medical, psychiatric , and religious discourses provide the fairly stable categories that the transforming state needs to order itself. Transsexual individuals, who seem understandably to prefer their privacy and control of their public personas, resist categorization.

BACKGROUND: The current study aimed to elucidate the protective role of combined fenugreek and a-tocopherol against cadmium induced histopathological changes in the testes. MATERIALS-METHODS: Thirty adult male albino rats divided into three equal groups 10 rats each. Group I is the control group. Group II received 5 mg/kg/ day cadmium chloride. Group III received 5 mg/kg/day cadmium chloride and 150 mg/kg/day fenugreek and 100 mg/kg/ day of a-tocopherol. The treatment of all groups was done by oral gavage for 60 consecutive days. The testes were removed and subjected to histopathological and ultrastructure study. RESULTS: Rats exposed to cadmium showed severe histopathological changes in the testicular spermatogenic series, many vacuoles and multinucleated giant cells. Treatment with fenugreek and a-tocopherol partially improved the morphological changes, reduced tissue damage and rebuilt of the spermatogonia layer. CONCLUSIONS: Fenugreek and a-tocopherol might represent a promising medicinal combination to ameliorate the toxic effects of cadmium exposure.

Young transpersons need to be informed about sexual health. Often health care givers only focus on their identity insecurity. Adult transpersons are at en extremely high risk for STI and HIV. Our youth clinic has investigated the 31 young persons with gender dysphoria who visited us during 2015.

MINERALOCORTICOID RECEPTORS in the Brain: The Key to Inability to Cope with Stress, Memory Loss, and, MAJOR DEPRESSION

and, oh yes,  the SUICIDE EPIDEMIC in the Transgender Community ! !

Why, because they are the first line of defense that allows proper coping with stress (and cortisol) in both the HIPPOCAMPUS and the AMYGDALA  and ultimately they are directly indicated in facilitating neurogenesis. Below are 16 Research Publications cited. We selected only a few comments verbatim from each. Truly they are a revelation

But first a word about something that the renowned Hans Selye said once, a long, long time ago, but which bears repeating.  We often speak about people being exposed to”stress”.  The first thing this understanding of the MR receptors might show us is how right Selye was when he said, “Stress is not what happens to us, but it is how we react to events in the environment”

Medical researchers themselves have been puzzled, shocked and astonished at how crucially  important to most things in life is the MR (mineralocorticoid receptor...including all our brain function).  They will talk about “stress” but they will show us that when the MR receptor is not working or blocked or not genetically normal, our reaction to events will be very different. And part of that reaction will be augmented and even uncontrolled cortisol activation in situations which don’t require it and a spiral of increasing depression.

It is also crucial to realize that with this neuroscience concern, as with ALL neuroscience concerns, ultimately the causation and thus the remediation depends on neurogenesis in the SVZ and the Dentate Gyrus.  In this instance, the MR receptor status and the actions of Aldosterone at the MR receptors are crucial in the modulation of ongoing neurogenesis that occurs every day in every way in the Amygdala and Hippocampus.

Hormone replacement therapy (HRT) in young postmenopausal women is a safe and effective tool to counteract climacteric symptoms and to prevent long-term degenerative diseases, such as osteoporotic fractures, cardiovascular disease, diabetes mellitus and possibly cognitive impairment. The different types of HRT offer to many extent comparable efficacies on symptoms control; however, the expert selection of specific compounds, doses or routes of administration can provide significant clinical advantages. This paper reviews the role of the non-oral route of administration of sex steroids in the clinical management of postmenopausal women. Non-orally administered estrogens, minimizing the hepatic induction of clotting factors and others proteins associated with the first-pass effect, are associated with potential advantages on the cardiovascular system. In particular, the risk of developing deep vein thrombosis or pulmonary thromboembolism is negligible in comparison to that associated with oral estrogens. In addition, recent indications suggest potential advantages for blood pressure control with non-oral estrogens. To the same extent, a growing literature suggests that the progestins used in association with estrogens may not be equivalent. Recent evidence indeed shows that natural progesterone displays a favorable action on the vessels and on the brain, while this might not be true for some synthetic progestins. Compelling indications also exist that differences might also be present for the risk of developing breast cancer, with recent trials indicating that the association of natural progesterone with estrogens confers less or even no risk of breast cancer as opposed to the use of other synthetic progestins. In conclusion, while all types of hormone replacement therapies are safe and effective and confer significant benefits in the long-term when initiated in young postmenopausal women, in specific clinical settings the choice of the transdermal route of administration of estrogens and the use of natural progesterone might offer significant benefits and added safety.