¿Es posible hablar de metafísica de la luz sin antes precisar qué es la ‘luz’? Parece esta una pregunta retórica o merecedora de una respuesta de Perogrullo, pero basta recorrer el argumento histórico que presenta el volumen en cuestión para ver que muchas propuestas no siempre siguieron este procedimiento intelectual. Desde su misma Introducción se explicitan las objeciones a abusos de la expresión ‘metafísica de la luz’ y también a interpretaciones metafísicas de las metáforas de la luz en los textos hexaemerales. A partir de estos reparos se expande el desafío central de esta tesis: no es suficiente diferenciar cuándo y cómo la terminología y simbolismos de la luz son utilizados de forma figurativa respecto de cuándo y cómo son no-figurativos. Los primeros (Lichtmetaphorik) pueden apuntar a una visión cosmológica o a lo sumo, una filosofía de la luz, mientras que los segundos (Lichtmetaphysik) representan una semántica analógica.

Ce privelişte! Mai tânărul asociat a lui Patterson, Dellhouse, se crede un bun cunoscător în materie de femei. Fata din faţa lui nu arăta ca alte cliente ce stăteau în confortabilul fotoliu din piele din biroul lui.-Am venit îndată ce am primit scrisoarea dumneavoastră, cea în care mi-aţi trimis biletul, spuse ea, pe un ton melodios, cu o mică ezitare înaintea ultimelor cuvinte. Alan Patterson tuşi, stânjenit.-Asociaţii mei au avut ideea să-l trimită, ne-am gândit că după moartea tatălui dumneavoastră, v-a fost greu să vă descurcaţi singură. Fata care stătea în partea cealaltă a biroului râse. Un zâmbet fugat, dar, care i-a transfigurat expresia fetei.-Mă bucur că v-aţi gândit la asta.-Şi acum să trecem la afaceri, propuse domnul Petterson, deschizând un dosar voluminos, ce-i fu înmânat de atenta şi isteaţa sa secretară.-Unde o or găsi oamenii haine ca acestea? Se întreba fiind preocupat de aspectul cliente sale, îmbrăcată într-un taior prost croit, tocit la coate şi un pulovor din lână, care o făcea mai palidă decât era. "Arată de parcă ar sta să leşine", se gândi el, "o fi bolnavă". Observă că avea pielea întinsă pe pomeţii proeminenţi şi o bărbie aspră, ochii adânciţi în orbite, ochelari cu rame de oţel. O mişcare bruscă a ploapelor la făcut să-şi dea seama că se uita fix la ea şi mai tuşi o dată, în chip de scuză.-Mă întrebam, zise el repede, dacă aţi luat micul dejun în tren. Fata negă.-Nu... nu mi-au ajuns... bani. Domnul Petterson apăsă pe butonul soneriei de pe birou. Apăru secretara.-Trimite imediat după sanviciuri, a ordonat, de pui, şuncă-orice găseşti-şi multă cafea. Secretara ridică din sprâncene.-Foarte bine, domnule, zise ea, cu un fel de reverenţă. Înţelegând nevoia urgentă de sandvişuri şi cafea, le-a adus imediat, de la barul alăturat.-Iată-le! exlamă domnul Petterson pe un ton fericit. Oferă-le domnişoare Mansford, să se servească. Văd că ai adus două ceşti, foarte bine, nu-mi strică nici mie o cafea. Secretara ieşi. Zaria Mansford rămase cu ochii aţintiţi la tavă, neştiind ce să facă cu strălucitoarele ceşti de cafea.-Cu sau fără lapte? Întrebă ea în cele din urmă.-Fără, răspunse domnul Petterson. Turnă cafea în ceaşcă şi i-o înmână peste birou. El refuză să ia sendviciuri şi atunci ea întins mâna spre tavă. Avea degetele foarte fine, cu vinişoare ce se zăreau sub pielea albă. "Bătrânul diavol trebuia să fi lăsat ceva bani", îşi zise domnul Petterson, apoi, întrebă cu voce tare:-Cred că nu mă înşel-tatăl dumneavoastră a murit acum trei luni. N-am avut prilejul să mă ocup de averea lui.-Nu! Era o firmă la Inverness, zise Zaria Mansford, "Mackenzie şi McLeod".

Accelerating digitization, algorithmic computation, artificial intelligence, and machine learning, along with the increasing automation of work, communication, and everyday life, are central to critical studies of technology and political economy, as well as to public discourse concerning technology's role in creating futures. Ongoing transformations in technological capacity have also been scrutinized for their impact on experience, emotion, and culture. Building on David Theo Goldberg's assertion that "tracking capitalism" creates pervasive dread, this article explores how the digital automation of education, specifically, generates forms of algorithmic anxiety that impact teaching and learning, constraining pedagogical visions of alternative futures. Algorithmic anxiety in education contributes to dread's proliferation. If dread is the "driving social sensibility" today, and algorithmic anxiety a pedagogical vector of its spread, then a less dreadful education should center an imaginative struggle for new sensibilities.

Abstrak Maksud dari penelitian ini adalah menduga umur simpan pasta bawang merah berdasarkan pendekatan Arrhenius dengan tujuan mengetahui berapa lama umur simpan pasta bawang merah pada kemasan yang berbeda dan suhu penyimpanan yang berbeda berdasarkan pendekatan Arrhenius. Pada penelitian ini dilakukan penelitian pendahuluan dan penelitian utama. Pada penelitian pendahuluan dilakukan penentuan varietas pasta bawang merah terpilih yang terdiri dari varietas Brebes, Sumenep dan Tuk-tuk dengan uji organoleptik serta uji karakteristik bawang merah dan pasta bawang merah. Sedangkan pada penelitian utama dilakukan pendugaan umur simpan dari pasta bawang merah terpilih yang dikemas alumunium foil dan kemasan gelas dengan pengujian parameter meliputi kadar air metode oven vacum, angka peroksida metode titrasi dan jumlah total mikroba metode total plate count. Hasil penelitian didapatkan bahwa kemasan yang cocok untuk pasta bawang merah adalah kemasan gelas. Berdasarkan data hasil perhitun...

Tissue damage is associated with pain, which is an alarming sign. Aspirin and morphine have been widely used in recent decades for management of pain. Medicinal herbs have been in use for treatment of different diseases for centuries. Many of these herbs possess analgesic activity with relatively less incidences of adverse effects. The strong positive correlation of alkaloids in medicinal plants for analgesic activity persuades an intention to determine possible analgesic activity of total alkaloids extracted from the selected medicinal plants using animal models to answer its possible mechanisms. Crude alkaloids from selected medicinal plants (Woodfordia fruticosa, Adhatoda vasica, Chenopodium ambrosioides, Vitex negundo, Peganum harmala and Broussonetia papyrifera) were extracted as per reported literature. The test crude alkaloids were screened foracute toxicity study. Writhings induced by acetic acid, tail immersion method and formalin-induced nociception assay procedures were u...

The Italian nephrology has a long tradition and experience in the field of dietetic-nutritional therapy (DNT), which is an important component in the conservative management of the patient suffering from a chronic kidney disease, which precedes and integrates the pharmacological therapies. The objectives of DNT include the maintenance of an optimal nutritional status, the prevention and/or correction of signs, symptoms and complications of chronic renal failure and, possibly, the delay in starting of dialysis. The DNT includes modulation of protein intake, adequacy of caloric intake, control of sodium and potassium intake, and reduction of phosphorus intake. For all dietary-nutritional therapies, and in particular those aimed at the patient with chronic renal failure, the problem of patient adherence to the dietetic-nutritional scheme is a key element for the success and safety of the DNT and it can be favored by an interdisciplinary and multi-professional approach of information, e...

Objetivo: El riesgo de desarrollar escoliosis de comienzo temprano es alto en niños con parálisis cerebral espástica, nivel IV y V del GMFCS. No hay acuerdo sobre el tratamiento para niños <5-6 años y esta revisión sistemática se centra en este tópico. Materiales y Métodos: Búsqueda en PubMed, Google Scholar, Cochrane Library, BVS/BIREME, LILACS y SciELO, entre enero de 2009 y noviembre de 2020, con los descriptores: “cerebral palsy, scoliosis, early-onset, treatment”. Se eliminaron los artículos duplicados, no relacionados con la investigación, sin texto completo, con pocos pacientes con parálisis cerebral espástica, sin discriminación etiológica, sin resultados y con edad avanzada. Evaluaciones: nivel de evidencia, edad, nivel del GMFCS, tipo de deformidades, tratamientos, seguimiento, resultados y complicaciones. Resultados: Se incluyeron 10 de 6770 artículos: 8 con nivel de evidencia IV, edad: 3.2-10 años, deformidad predominante: escoliosis, seguimiento: 1.5-9.8 años. Tratam...

IntroductionInflammatory joint diseases such as rheumatoid arthritis are associated with local bone erosions and systemic bone loss, mediated by increased osteoclastic activity. The receptor activator of nuclear factor (NF) κB ligand (RANKL) plays a key role in mediating inflammation-induced bone loss, whereas tumour necrosis factor (TNF) plays a central role in the inflammatory process. Here we tested whether a recently identified class of small molecule inhibitors of RANKL signalling (ABD compounds) also affect TNF signalling and whether these compounds inhibit inflammation in an animal model of rheumatoid arthritis.MethodsThe inhibitory effects of the ABD compounds on TNF-induced signalling were tested in mouse macrophage cultures by western blotting and in an NFκB luciferase-reporter cell line. The anti-inflammatory effects of the compounds were tested in the mouse collagen-induced arthritis model of rheumatoid arthritis.ResultsThe ABD compounds ABD328 and ABD345 both inhibited ...

IntroductionThere is a continuous debate concerning the superiority of endotracheal intubation on bag-valve-mask (BVM) ventilation in patients with cardiac arrest. In this manikin-based observational study, we evaluate and compare the performance of manual ventilation through a facemask (BVM) and an endotracheal tube (ETT).MethodsOne hundred and forty healthcare providers were instructed to manually ventilate a manikin as they would do for a 75 kg adult patient in respiratory arrest. Each one was ventilating both through a facemask and an ETT for a 5 min period in a random order. Ventilatory parameters were measured by the ASL 5000 lung simulator and ventilation performance was analysed using a sliding window method published in a previous study to assess accurately ventilation efficiency.ResultsThe mean ventilation rate was high whatever the technique used (24 bpm). A weak relationship between manual ventilation performance and the type of interface used was observed (p=0.0484). Th...

Background Neosaxitoxin is a phycotoxin that reversibly blocks the voltage-gated sodium channels at the neuronal level. Its activity results in blocking the axonal conduction, stopping the propagation of the nerve impulse. The objective of the present work was to evaluate neosaxitoxin as a local anesthetic in a human trial. Methods The authors conducted a randomized, double-blind, placebo-controlled trial with 10 healthy volunteers. Subcutaneous injections were made in the middle posterior skin of the calf: one leg received 50 microg neosaxitoxin, and the contra-lateral leg received placebo. The anesthetic effect was evaluated using a standardized human sensory and pain model. TSA II Neurosensory Analyzer (Medoc Ltd, Minneapolis, MN) and von Frey technique were used to evaluate five parameters: sensory threshold for warm and cold, pain thresholds for heat and cold, and mechanical touch perception threshold. Measurements were made 0, 1, 3, 6, 9, 12, 16, 24, and 48 h after the injecti...