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2002, Clinical Autonomic Research
Gustatory sweating results from a disruption of the auriculotemporal nerve pathways. Damage to the nerve or its branches may cause a misdirected re-growth that results in parasympathetic innervation of sympathetic receptors.Following the re-growth period,patients may report that gustatory stimulation leads to episodes of facial sweating and flushing.Most of the early literature on gus-tatory sweating failed to adequately address the causes and treatments of this phenomenon. Lucja ) systematically investigated gustatory sweating, which is now referred to as Frey's syndrome.
Objective: To review the chronology of publications on gustatory sweating before Frey's landmark publication. Methods: Reports on Frey syndrome were reviewed, and all references given to publications before 1950 were obtained and examined. References to prior publications in the obtained articles were similarly reviewed. The cases described in these publications were analyzed for their compatibility with the accepted clinical symptoms of Frey syndrome. Results: Despite numerous references, the case described by Duphenix in 1757 is most probably a traumatic parotid fistula. The first reported case of Frey syndrome should be attributed to Baillarger in 1853.
Surgeon-journal of The Royal Colleges of Surgeons of Edinburgh and Ireland
Lucja Frey — historical relevance and syndrome review2008 •
The goal of this work is to present our results of the intradermic infiltration with botulinum toxin in patients with Frey syndrome. Sixteen hemifaces in 15 patients were studied. Gustatory stimulation was evoked by sucking on a slice of lemon while measurements were done on both hemifaces, with the normal side being used as a control. Skin temperature and color (erythema) were measured with a digital surface thermometer and a skin chromame-ter, respectively. Sweat quantity and surface were measured by using the previously described blotting paper and iodine-sublimated paper histogram methods, respectively. Testing was repeated 2 weeks after skin infiltration with botulinum toxin (dilution of 50 U/mL). The interinjection distances were 1 cm, and 0.1 mL (5 U) was infiltrated at each injection site. Frey syndrome complaints disappeared in all patients. Small residual amounts of sweat were measurable. The difference in sweat quantity before and after botulinum toxin infiltration was significant in every patient (P < 0.001). Skin temperature and color measurement gave inconclusive results. In conclusion, Frey syndrome treatment with botulinum toxin is an efficient and well-tolerated technique. Further work should address the optimal injection parameters. (Otolaryngol Head Neck Surg 2000;122:821-7.)
The Laryngoscope
The use of acellular dermis in the prevention of Frey's syndrome2001 •
At the conclusion of this presentation, the participant should be able to discuss the indications and advantages of using acellular dermis in the prevention of post-parotidectomy gustatory sweating (Frey's Syndrome). Gustatory sweating is a common postoperative problem and a challenge to treat. The purpose of this study was to evaluate the role of acellular dermis in preventing post-parotidectomy gustatory sweating. Sixty-four patients were randomly assigned to two groups. Group I consisted of 32 patients who underwent a superficial lobe parotidectomy. Group II consisted of 32 patients who underwent a superficial lobe parotidectomy and underwent intraoperative placement of acellular dermis within the parotid bed, between the skin flap and the remaining parotid tissue. The implanted volume of acellular dermis was determined by the amount required to aesthetically restore lateral facial contour. All 64 patients were evaluated for gustatory sweating by identical phone and mail ques...
1997 •
Clinical Autonomic Research
The role of gustatory flushing in Frey's syndrome and its treatment with botulinum toxin type A2002 •
Objective: To evaluate the incidence of Frey syndrome (auriculotemporal nerve syndrome) after paroti-dectomy with and without placement of a subcutaneous implant and to examine the relationship between different implants and postoperative wound complications (he-matoma, seroma, salivary fistula).

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