Pharmacognosy and Phytochemistry

ANTIMICROBIAL POTENTIAL OF VOLATILE OIL ISOLATED FROM SOME TRADITIONAL INDIAN SPICES

by Saumendu Deb Roy

Deb Roy Saumendu*, Talukdar Apu, Saikia Dhrubajyoti, Kashyap Arunav, Bhuyan Anupam, Das Bidyut.
Published in International Research Journal of Pharmacy'2012

In the present study the antimicrobial activity of Volatile Oils isolated from Traditional Indian Spices, Anethum... more In the present study the antimicrobial activity of Volatile Oils isolated from Traditional Indian Spices, Anethum Graveolens (Umbelliferae), Foeniculum Vulgare (Umbelliferae) and Coriandrum Sativum (Umbelliferae) were studied. The isolated Volatile Oils in varying concentrations were studied against Staphylococcus Coagulase, E.Coli, Streptococcus fecaelis and Staphylococcus aureus, by paper disc diffusion method, using Amoxicillin as standard drug.
The results indicated that all the Volatile Oil samples from Anethum Graveolens (Dill), Foeniculum Vulgare (Fennel) and Coriandrum Sativum (Coriender) has antimicrobial potential and were active against almost all the microorganisms but in a dose dependent manner. Foeniculum Vulgare by far was the most potent volatile oil showing the highest activity against Staphylococcus Coagulase.

Estimation of lornoxicam in tablet dosage form by UV spectrophotometric method

by Saumendu Deb Roy

Antiulcer Activity of Ethanolic Extract of Whole Plant of Scutia myrtina

by Saumendu Deb Roy

IN VITRO ANTIBIOTIC ACTIVITY OF VARIOUS EXTRACTS OF GYMNEMA SYLVESTRE

by Saumendu Deb Roy

The main aim of the research work is to confirm the ethno medicinal claim that Gymnema Sylvestre
has got... more The main aim of the research work is to confirm the ethno medicinal claim that Gymnema Sylvestre
has got antimicrobial activities which could be a better alternative for synthetic antimicrobials, if proved
to be effective enough. For this we have extracted Gymnema Sylvestre with Petroleum Ether then with
Chloroform and lastlty with a mixture of Water:Ethanol (1:1), using Soxhlet Apparatus. Antibacterial
activity of different extracts were evaluated by “Paper Disc Diffusion Method” against Bacillus Subtilis,
Staphylococcus Aureus and Escherichia Coli using Erythromycin as a standard and DMSO as Control
Sample. Zone of inhibition of Bacillus Subtilis and Staphylococcus Aureus were found respectively when
compared with the result of the Standard, while Extracts had no activity against E.Coli. So, in future the
leaves of this plant can be used for selective infections and can be further explored for isolation of the
active principles responsible for antimicrobial property.

PHYTOCHEMICAL SCREENING AND GUT MOTILITY ACTIVITY OF ETHANOLIC EXTRACT OF WHOLE PLANT OF SCUTIA MYRTINA KURZ.

by Saumendu Deb Roy

Phytochemical and Gut motility activity of Ethanolic Extract of whole plant of Scutia Myrtina Kurz collected from... more Phytochemical and Gut motility activity of Ethanolic Extract of whole plant of Scutia Myrtina Kurz collected from Kolli Hills, Tamil Nadu was studied. Phytochemical studies revealed the presence of Alkaloids, Glycosides (Anthraquinone), Flavonoids and Tannins. For Gut Motility activity Extracts in concentration of 200mg/Kg and 400mg/Kg were studied in three animal models in comparison to Caster Oil and Glaxenna; (a) Gut motility activity in isolated Rat Intestine, (b) Propulsive Gut motility in mice & (c) Laxative activity in Mice. The Gut motility activity was assessed by different parameters depending on respective animal models. Caster Oil and Glaxenna were used as Standard drugs depending on the animal models. Gut motility in the test drug treated animals were found to be significant in all the models. Anthraquinone Glycosides present in the drug is probably responsible for the Gut motility activity.

Antiulcerogenic activity of Saussurea lappa root

by Saumendu Deb Roy

The study was designed to investigate the antiulcer activity of ethyl acetate extract of the Saussurea lappa root... more The study was designed to investigate the antiulcer activity of ethyl acetate extract of the Saussurea lappa root using different models of gastric and duodenal ulceration in rats. Gastric ulcers were induced by oral administration of ethanol, aspirin and by pyloric ligation and duodenal ulcers were induced by oral administration of cysteamine HCl. The extract was administered at a dose of 200 and 400 mg/kg orally 30 min prior to ulcer induction. Ranitidine (50 mg/kg) was used as a reference standard. The antiulcer activity was accessed by determining and comparing the ulcer index in the test group with that of the standard drug treated group. Gastric volume, total acid and free acid were estimated in the pylorus-ligated rats. Saussurea lappa root (400mg/kg) showed maximum inhibition of gastric acid, free acid and total acid to 53.54%, 52.55% and 30.30%, respectively. The ulcer index in the Saussurea lappa root treated animals was found to be significantly less in all the models compared to standard drug treated cases. The antiulcer activity of Saussurea lappa root was, however, less than that of ranitidine. The results suggest that Saussurea lappa root possesses significant antiulcer property which could be due to cytoprotective action of the drug or strengthening of gastric and duodenal mucosa with the enhancement of mucosal defense.

Prospects, Problems & Approaches To Alternative System Of Medicine: A Review

by Saumendu Deb Roy

There is a trend for synthetics to replace natural compounds in Prescription and Over the Counter (OTC)... more There is a trend for synthetics to replace natural compounds in Prescription and Over the Counter (OTC) Pharmaceuticals. Today, ephedrine, salicylates, vitamins, and xanthines are mostly synthetic and steroids are often semi synthetic. While agreeing with Farnsworth and Bingel (1977) that 25% of modern prescription drugs contain at least one phytochemical, I suspect that only about 10% of our leading drugs (excluding the illicit drugs, cocaine, crack, hashish, heroin, marijuana, and opium) now contain phytochemicals still extracted directly from the higher plants. Due to their long historical clinical use and reliable therapeutic efficacy, traditional Indian medicine attract and increase global attention, and many big pharmaceutical companies are using traditional Indian medicine as an excellent pool for discovering natural bioactive compounds. If only few constituents are emphasized, the holistic nature will be neglected, which needs to be studied and scientifically understood. With the growing need for safer drugs, attention has been drawn to their quality, efficacy and standards of the traditional Indian medicine formulations

High-performance liquid chromatography-diode array detection-electrospray ionization multi-stage mass spectrometric screening of an insect/plant system: the case of Spodoptera littoralis/Lycopersicon esculentum phenolics and alkaloids

by Marcos Taveira

Qualidade de produtos a base de plantas medicinais comercializados no Brasil: castanha-da-índia (Aesculus hippocastanum L.), capim-limão (Cymbopogon citratus ( …

by Ulysses Albuquerque

Influence of biflorin on the labelling of red blood cells, plasma protein, cell protein, and lymphocytes with technetium-99m: in vitro study

by Ulysses Albuquerque

Interpenetrating polymeric network hydrogel for stomach-specific drug delivery of clarithromycin: Preparation and evaluation

by Ram C Dhakar

Dhakar Ramchand1, Gupta Anish Kumar, Siddiqui Abdul Wadood, Maurya Sheo Datta1,

The aim of this study was to develop a controlled release system targeting antibiotic delivery to the stomach. Themore The aim of this study was to develop a controlled release system targeting antibiotic delivery to the stomach. The
hydrogels were synthesized by using chitosan, poly (acrylic acid) and poly (vinyl pyrrolidone) polymers crosslinked
with glutaraldehyde and N,N’-methylenebisacrylamide. Interpenetrating polymeric network (IPN) hydrogels were prepared
by varying the concentration of crosslinking agent (glutaraldehyde). The amount of chitosan, poly (acrylic acid), poly
(vinyl pyrrolidone) and N,N’-methylenebisacrylamide were kept constant in all formulations. The effect of glutaraldehyde
concentration on the swelling and release characteristics were evaluated. Modalities used to assess the most optimal hydrogel
formulation included high liquid chromatography, FTIR analysis, differential scanning calorimetry, swelling studies, in vitro
drug release study, mucoadhesive study and scanning electron microscopy. The result showed that IPN hydrogels were
greater in swelling, more mucoadhesive and released more drug at lower pH values. Thus, it is believed that the antibiotic
concentration in the stomach might be sustained through this formulation.

A review of the herbal phosphodiesterase inhibitors; future perspective of new drugs

by haniye azimi

"Co-authored with Rahimi R, Ghiasi S, Fakhari S and Abdollahi M", "published in "Cytokine", 2010