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Seen by:PREGUNTA ESTRUCTURADA Y BÚSQUEDA DE LA LITERATURA MÉDICA: EL PRIMER PASO EN LA PRÁCTICA DE LA MEDICINA BASADA EN LA EVIDENCIA
Revista de la Facultad Ciencias de la Salud de la Universidad del Cauca, Volumen 13 Numero 4, Diciembre de 2010
ISSN 0124-308X
Este artículo busca ilustrar a profesionales de la salud sobre la importancia y utilidad de la Medicina Basada en la... more Este artículo busca ilustrar a profesionales de la salud sobre la importancia y utilidad de la Medicina Basada en la Evidencia (MBE) como un método para la toma de decisiones clínicas en el ejercicio actual de la medicina y se enfoca en el primer paso: ¿Cómo estructurar una pregunta clínica de manera que se facilite el acceso a la respuesta en las bases de literatura biomédica como PubMED y la Librería Cochrane? El empleo de preguntas estructuradas permiten ahorrar tiempo en la recuperación de las referencias de la literatura científica pertinentes a la pregunta de intervención o tratamiento y consta de cuatro componentes: Pacientes, intervención, comparación y resultados (Outcomes). Los términos de la pregunta estructurada y la combinación de los mismos constituyen uno de los elementos de la estrategia de búsqueda, que también es de utilidad en la construcción de un estado del arte o un marco teórico en un proyecto de investigación.
Interventions for female pattern hair loss
Esther J van Zuuren, Zbys Fedorowicz, Ben Carter, Régis B Andriolo, Jan Schoones
Background
Female pattern hair loss, or androgenic alopecia, is the most common type of hair loss affecting... more
Background
Female pattern hair loss, or androgenic alopecia, is the most common type of hair loss affecting women. It is characterised by progressive shortening of the duration of the growth phase of the hair with successive hair cycles, and progressive follicular miniaturisation with conversion of terminal to vellus hair follicles (terminal hairs are thicker and longer, while vellus hairs are soft, fine, and short). The frontal hair line may or may not be preserved. Hair loss can have a serious psychological impact on people.
Objectives
To determine the effectiveness and safety of the available options for the treatment of female pattern hair loss in women.
Search methods
We searched the following databases up to October 2011: the Cochrane Skin Group Specialised Register, CENTRAL in The Cochrane Library (2011, Issue 4), MEDLINE (from 1946), EMBASE (from 1974), PsycINFO (from 1806), AMED (from 1985), LILACS (from 1982), PubMed (from 1947), Web of Science (from 1945), and reference lists of articles. We also searched several online trials registries for ongoing trials.
Selection criteria
Randomised controlled trials that assessed the effectiveness of interventions for female pattern hair loss in women.
Data collection and analysis
Two review authors independently assessed trial quality and extracted data.
Main results
Twenty two trials, comprising 2349 participants, were included. A wide range of interventions were evaluated, with 10 studies investigating the different concentrations of minoxidil. Pooled data from 4 studies indicated that a greater proportion of participants (121/488) treated with minoxidil reported a moderate increase in their hair regrowth when compared with placebo (64/476) (risk ratio (RR) = 1.86, 95% confidence interval (CI) 1.42 to 2.43). In 7 studies, there was an important increase of 13.28 in total hair count per cm² in the minoxidil group compared to the placebo group (95% CI 10.89 to 15.68). There was no difference in the number of adverse events in the twice daily minoxidil and placebo intervention groups, with the exception of a reported increase of adverse events (additional hair growth on areas other than the scalp) with minoxidil (5%) twice daily. Most of the other comparisons consisted of single studies. These were assessed as high risk of bias: They did not address our prespecified outcomes and provided limited evidence of either the efficacy or safety of these interventions.
Authors' conclusions
Although more than half of the included studies were assessed as being at high risk of bias, and the rest at unclear, there was evidence to support the effectiveness and safety of topical minoxidil in the treatment of female pattern hair loss. Further direct comparison studies of minoxidil 5% applied once a day, which could improve adherence when compared to minoxidil 2% twice daily, are still required. Consideration should also be given to conducting additional well-designed, adequately-powered randomised controlled trials investigating several of the other treatment options.
Defusing the "time-bomb": clarifying annotation 3.13 [Letter]
Ryan, Christopher James, John Adams, Peter Miller, Ian Sale, Sidney Bloch, Daniel Sullivan, George Mendelson, Fred Ng, Jimsie Cutbush, and Carol Newlands. 2011. Defusing the "time-bomb": clarifying annotation 3.13 [Letter]. Australasian Psychiatry 19 (3): 269.
As those on the Committee that framed the College's recent revision of its Code of Ethics, we could understand, but... more As those on the Committee that framed the College's recent revision of its Code of Ethics, we could understand, but were a little dismayed by, Dr Morstyn’s apparent misunderstanding of annotation 3.13. We worry that others may share his concerns and hope that the comments below might assist in clarifying the annotation's intended meaning.
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Seen by:Mechanistic evidence: Disambiguating the Russo-Williamson Thesis
International Studies in the Philosophy of Science. 25(2), (2011): 139–57.
DOI:10.1080/02698595.2011.574856
Russo and Williamson claim that establishing causal claims requires mechanistic and difference-making evidence. In this... more Russo and Williamson claim that establishing causal claims requires mechanistic and difference-making evidence. In this paper, I will argue that Russo and Williamson’s formulation of their thesis is multiply ambiguous. I will make three distinctions: mechanistic evidence as type vs object of evidence; what mechanism or mechanisms we want evidence of; and how much evidence of a mechanism we require. I will feed these more precise meanings back into the Russo-Williamson Thesis and argue that it is both true and false: two weaker versions of the thesis are worth supporting, while the stronger versions are not. Further, my distinctions are of wider concern because they allow us to make more precise claims about what kinds of evidence are required in particular cases.
Development and validation of filters for the retrieval of studies of clinical examination from Medline
Co-authored with Nader Shaikh, MD MPH,corresponding author1 Robert G Badgett, MD,2 Mina Pi, BS,3 Nancy L Wilczynski, PhD,4 K. Ann McKibbon, PhD,4 and R. Brian Haynes, MD PhD4. Originally published in the Journal of Medical Internet Research.
Background
Efficiently finding clinical examination studies—studies that quantify the value of symptoms and signs... more
Background
Efficiently finding clinical examination studies—studies that quantify the value of symptoms and signs in the diagnosis of disease—is becoming increasingly difficult. Filters developed to retrieve studies of diagnosis from Medline lack specificity because they also retrieve large numbers of studies on the diagnostic value of imaging and laboratory tests.
Objective
The objective was to develop filters for retrieving clinical examination studies from Medline.
Methods
We developed filters in a training dataset and validated them in a testing database. We created the training database by hand searching 161 journals (n = 52,636 studies). We evaluated the recall and precision of 65 candidate single-term filters in identifying studies that reported the sensitivity and specificity of symptoms or signs in the training database. To identify best combinations of these search terms, we used recursive partitioning. The best-performing filters in the training database as well as 13 previously developed filters were evaluated in a testing database (n = 431,120 studies). We also examined the impact of examining reference lists of included articles on recall.
Results
In the training database, the single-term filters with the highest recall (95%) and the highest precision (8.4%) were diagnosis[subheading] and “medical history taking”[MeSH], respectively. The multiple-term filter developed using recursive partitioning (the RP filter) had a recall of 100% and a precision of 89% in the training database. In the testing database, the Haynes-2004-Sensitive filter (recall 98%, precision 0.13%) and the RP filter (recall 89%, precision 0.52%) showed the best performance. The recall of these two filters increased to 99% and 94% respectively with review of the reference lists of the included articles.
Conclusions
Recursive partitioning appears to be a useful method of developing search filters. The empirical search filters proposed here can assist in the retrieval of clinical examination studies from Medline; however, because of the low precision of the search strategies, retrieving relevant studies remains challenging. Improving precision may require systematic changes in the tagging of articles by the National Library of Medicine.
Impact of facilitating physician access to relevant medical literature on outcomes of hospitalised internal medicine patients: a randomised controlled trial
Introduction There is limited high-quality evidence regarding the usefulness of bibliographic assistance in improving... more
Introduction There is limited high-quality evidence regarding the usefulness of bibliographic assistance in improving clinically important outcomes in hospitalised patients. This study was designed to evaluate the impact of providing attending physicians with bibliographic information to assist them in answering medical questions that arise during daily clinical practice.
Methods All patients admitted to the Internal Medicine ward of Hospital Aleman in Buenos Aires between March and August 2010 were randomly assigned to one of two groups: intervention or control. Throughout this period, the medical questions that arose during morning rounds were identifi ed. Bibliographic research was conducted to answer only those questions that emerged during the discussion of patients assigned to the intervention group.
The compiled information was sent via e-mail to all members
of the medical team.
Results 809 patients were included in the study, 407 were randomly assigned to a search-supported group and 402 to a control group. There was no signifi cant difference in death or transfer to an intensive care unit (ICU) (RR 1.09 (95% CI 0.7 to 1.6)), rehospitalisation (RR 1.0 (95% CI 0.7 to 1.3)) or length of hospitalisation (6.5 vs 6.0 days, p=0.25). The subgroup of search-supported physicians’ patients (n=31), whose attending physicians received hand-delivered information, had a signifi cantly lower risk of death or transfer to an ICU compared with the
control group (0% vs 13.7%, p=0.03).
Conclusions The impact of bibliographic assistance on clinically important outcomes could not be proven by this study. However, results suggest that some interventions, such as delivering information by hand, might be benefi cial in a subgroup of inpatients.
The Collaborative Patient/Person-Centric Care Model (CPCCM) Introducing a new paradigm in patient care involving an evidence-informed approach. Canadian Healthcare Network. EPublished 7 March 2011. http://www.canadianhealthcarenetwork.ca/
Official Citation for references:
Lamoure J., Stovel J., Piamonte M., Benbow S., Singh P., Steenstra J., Singh P., Moore K, Burgess S. The Collaborative Patient/Person-Centric Care Model (CPCCM) Introducing a new paradigm in patient care involving an evidence-informed approach. Canadian Healthcare Network. EPublished 7 March 2011. http://www.canadianhealthcarenetwork.ca/
Contact: jlamour@uwo.ca
"Patient care has traditionally been guided by the conventional paradigm known as the medical or biomedical... more
"Patient care has traditionally been guided by the conventional paradigm known as the medical or biomedical model, whose roots can be traced back to the era of reductionism and mind-body dualism, which separates the mental from the somatic. (Engel, 1977) In this model, disease is defined as a biophysical malfunction. (Engel, 1977) In the biomedical model, the goal of treatment is to correct the malfunction in order to cure the disease. (Engel, 1977) As such, this traditional medical model places the pathophysiology of the disease, objective tests, and therapeutic interventions at the centre of patient care. (McCollum, 2009) Such a model offers a one-dimensional approach to patient care that excludes the patient experience of illness and how this might impact other facets of the patient’s life (e.g., work disability, finances, social networks, etc.) because they are believed to lie outside of medicine’s responsibility and authority. (McCollum, 2009; Engel, 1977)
By incorporating other psychological (e.g., thoughts, emotions, behaviors) and social dimensions of the patient into the care plan, one moves towards the bio-psycho-social (BPS) model of patient care. (Phelps, 2009) The BPS model was first theorized by a psychiatrist, Dr. George L. Engel, in 1977. (Engel, 1977) In the BPS model, patient care is based on the belief that psychological and social dimensions also contribute significantly to human functioning within the context of disease or illness and, as such, need to be considered when providing care to a patient. (Engel, 1977) Specifically, the biological component examines the cause of the illness and how it affects the functioning of the body. (Engel, 1977) The psychological component of the model explores any potential psychological causes for the illness (e.g., lack of self-control, emotional stressors, negative-thinking, etc.). (Engel, 1977) Finally, the social component considers how different social factors (e.g., socioeconomic status, religion, culture, etc.) impact illness. (Engel, 1977) In order to address all aspects of this three-dimensional model, an integrated team approach involving allied healthcare professionals such as physicians, nurses, psychologists, pharmacists, social workers, and rehabilitation specialists are critical for ensuring that more comprehensive patient care is provided. (Phelps, 2009) Overall, the underlying premise of the BPS model is that the body and mind are intricately connected and what affects one will affect the other. (Halligan, 2006; Freudenreich, 2010) However, while this model advances patient care and can address the dis-ease that exists within the disease, it still does not encompass the patient as a “whole” and consider all the multitude of facets that make up the individual.
An alternative model to the biomedical and BPS model of care is the recovery model. In the recovery model, the patient is involved in a lifelong recovery process that involves a number of incremental steps across various facets of his or her life. (Turton, 2010) Moreover, the primary illness is seen as only one dimension in the patient’s recovery process. (Turton, 2010) Other key aspects of this model include negotiating treatment approaches between patients and practitioners such that the patient feels empowered. (Turton, 2010) Moreover, this model enables patients to regain their dignity and identity beyond the illness. (Turton, 2010) As such, this model takes the BPS model and advances it forward to include other patient dimensions in the provision of their care. Thus, the underlying ethos of this model for the patient is one of hope and optimism. (Turton, 2010)
A recent study conducted in ten European countries aimed to examine the recovery model of patient care in order to identify aspects of care that key stakeholders believed to be most important in the promoting recovery, specifically in patients with mental illness. (Turton, 2010) Eleven important domains of care identified by stakeholders in this study included: (1) social policy and human rights, (2) social inclusion, (3) self-management and autonomy, (4) therapeutic interventions, (5) governance, (6) staffing, (7) staff attitudes, (8) institutional environment, (9) post-discharge care, (10) caregivers, and (11) physical health care. (Turton, 2010) The authors also found that there was generally a high consensus between groups and countries with some modest differences in priorities noted. (Turton, 2010) Interesting, the most highly rated aspect of care was therapeutic interventions, a central piece of the more traditional medical model of care. (Turton, 2010) The authors suggest that stakeholders may still hold therapeutic interventions as the most important aspect of care because such interventions form the foundation and ‘raison d’être’ of health care. (Turton, 2010) Thus, it may be difficult for practitioners to step away from convention and embrace a new paradigm.
Incorporating various aspects of the BPS and recovery model of patient care, a patient-centered care (PCC) model has evolved over the last several years to replace the conventional biomedical model of care. (Laird-Fick, 2010) The Institute of Medicine (IOM) has stated that embracing a PCC model will help to close the “quality chasm” often present in the care provided to patients. (IOM, 2001) In a PCC model, the patient’s individuality is central. (Wolf, 2008) The patient has the right to have his or her needs, desires, beliefs, values, and goals respected and placed at the centre of the care plan. (Laird-Fick, 2010; Wolf, 2008) Such respect of the patient’s individuality is part of the team’s commitment to understand the patient’s perspective of his or her own health status and subsequent care. (Wolf, 2008) The underlying ethos of this model of care is that the patient has the right to respect, dignity, and care that focuses on the person and situation versus the disease process. (Wolf, 2008)
Our hypothesis is that the medical and bio-psycho-social models act as an essential foundation on which a more patient functionality centered model evolves: the Collaborative Patient/Person-Centric Care Model (CPCCM). This has a paradigm shift in the deliverables of patient care which involves talking to patients and family, listening to their desired outcomes, collaborating with allied health team members in order to help facilitate these patient goals, and finally formulating an individualized care plan that combines the patient’s wishes with the clinical endpoints derived from a uniform therapeutic thought process. The root of this theory is enmeshed in goal driven outcomes, as are the other models. However the goal is driven by the patient and then filtered through the professional lenses of the members of the treating team versus the converse. This evidence-informed versus evidence-based approach is more patient centric than when outcomes are determined independently by clinicians in a traditional hierarchical structure. This also allows the current structure to be realigned along a linear axis. (Lamoure 2008)" Joel Lamoure, Jessica Stovel, Matthew Piamonte et al.
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Seen by: and 13 moreTowards a new paradigm in health research and practice? Collaborations for Leadership in Applied Health Research and Care
Martin GP, McNicol S, Chew S. Towards a new paradigm in health research and practice? Collaborations for Leadership in Applied Health Research and Care. Journal of Health Organization & Management in press. Please contact author for a copy.
Purpose: CLAHRCs are a new UK initiative to promote collaboration between universities and healthcare organisations in... more
Purpose: CLAHRCs are a new UK initiative to promote collaboration between universities and healthcare organisations in carrying out and applying the findings of applied health research. But they face significant, institutionalised barriers to their success. This paper analyses these challenges and discusses prospects for overcoming them.
Design: We draw on in-depth qualitative interview data from the first round of an ongoing evaluation of one CLAHRC to understand the views of different stakeholders on its progress so far, challenges faced, and emergent solutions.
Findings: The breadth of CLAHRCs’ missions seems crucial to mobilise the diverse stakeholders needed to succeed, but also produces disagreement about what the prime goal of the Collaborations should be. A process of consensus building is necessary to instil a common vision among CLAHRC members, but deep-seated institutional divisions continue to orient them in divergent directions, which may need to be overcome through other means.
Originality/value: Our analysis suggests some of the key means by which those involved in joint enterprises such as CLAHRCs can achieve consensus and action towards a current goal, and offers recommendations for those involved in their design, commissioning and performance management.
Review of Ron SHAHAM, The Expert Witness in Islamic Courts: Medicine and Crafts in the Service of the Law.
Book Reviews Journal of the Economic and Social History of the Orient JESHO 54 (2011) 270-309
Expert witness is an important part of Muslim court procedures in the pre-modern age. This book provides a good... more Expert witness is an important part of Muslim court procedures in the pre-modern age. This book provides a good history of this practice.
Deconstructing the Evidence-Based Discourse in Health Sciences: Truth, Power, and Fascism
co-authored with Dave Holmes, Amélie Perron, and Geneviève Rail, International Journal of Evidence-Based Healthcare, vol. 4, no. 3 (2006): 180-186
Background: Drawing on the work of the late French philosophers Deleuze and Guattari, the objective of this paper is... more
Background: Drawing on the work of the late French philosophers Deleuze and Guattari, the objective of this paper is to demonstrate that the evidence-based movement
in the health sciences is outrageously exclusionary and dangerously normative with regards to scientific knowledge. As such, we assert that the evidence-based movement in health sciences constitutes a good example of microfascism at play in the contemporary scientific arena.
Objective: The philosophical work of Deleuze and Guattari proves to be useful in showing how health sciences are colonised (territorialised) by an all-encompassing cientific research paradigm – that of post-positivism – but also and foremost in showing the process by which a dominant ideology comes to exclude alternative forms of knowledge, therefore acting as a fascist structure.
Conclusion: The Cochrane Group, among others, has created a hierarchy that has been endorsed by many academic institutions, and that serves to (re)produce the exclusion of certain forms of research. Because ‘regimes of truth’ such as the evidence-based movement currently enjoy a privileged status, scholars have not only a cientific duty, but also an ethical obligation to deconstruct these regimes of power.
No Exit? Intellectual Integrity Under the Regime of 'Evidence' and 'Best-Practices'
co-authored with Dave Holmes, Amélie Perron, and Geneviève Rail, Journal of Evaluation in Clinical Practice, vol. 13, no. 4 (2007): 512-516
No exit? Have we arrived at an impasse in the health sciences? Has the regime of ‘evidence’, coupled with corporate... more No exit? Have we arrived at an impasse in the health sciences? Has the regime of ‘evidence’, coupled with corporate models of accountability and ‘best-practices’, led to an inexorable decline in innovation, scholarship, and actual health care? Would it be fair to speak of a ‘methodological fundamentalism’ from which there is no escape? In this article, we make an argument about intellectual integrity and good faith. We take this risk knowing full well that we do so in a hostile political climate in the health sciences, positioning ourselves against those who quietly but assiduously control the very terms by which the public faithfully understands ‘integrity’ and ‘truth’. In doing so, we offer an honest critique of these definitions and of the systemic power that is reproduced and guarded by the gatekeepers of ‘Good Science’.
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