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Seen by:Metformin Treatment of Diabetes Mellitus Increases the Risk for Pancreatitis In Patients Bearing the CFTR-Mutation S573C
Patthara Kongsuphol, Diane Cassidy, Francisco Romeiras, Rainer Schreiber, Anil Mehta, Karl Kunzelmann (2010) “Metformin treatment of diabetes mellitus increases the risk for pancreatitis in patients bearing the CFTR-mutation S573C”. Cell Physiol Biochem. 25:389-396
Talking about depression: a qualitative study of barriers to managing depression in people with long term conditions in primary care.
by Rebecca Hays
Published in BMC Family Practice, 2011.
Co-authored with Peter Coventry, Chris Dickens, Christine Bundy, Charlotte Garrett, Andrea Cherrington and Carolyn Chew-Graham.
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Seen by:Accessing primary health care: a meta-ethnography of the experiences of British South Asian patients with diabetes, coronary heart disease or a mental health problem
by Rebecca Hays
Published in Chronic Illness, 2012.
Co-authored with Charlotte Garrett, Linda Gask, Andrea Cherrington, Christine Bundy, Chris Dickens, Waquas Waheed and Peter Coventry.
Preparation and Characterization of Pioglitazone Loaded PLGA Nanospheres for the Treatment of Type 2 Diabetes
Article in press "Polymer (Korea),
Vol.34, No.6, 527 - 533, 2010
The pioglitazone loaded poly(lactide-co-glycolide)(PLGA) nanospheres were prepared by emulsion-evaporation method and... more
The pioglitazone loaded poly(lactide-co-glycolide)(PLGA) nanospheres were prepared by emulsion-evaporation method and optimized for particle size and entrapment efficiency. The optimized particles were 125∼170 nm in size with narrow size distribution and showed above 85% entrapment efficiency at 30% of pioglitazone loading when prepared with 3% w/v of poly(vinyl alcohol) (PVA) as a surfactant. These particulate carriers exhibited a controlled in vitro release of pioglitazone for 40 days at a nearly constant rate. The pioglitazone loaded PLGA nanospheres were not only effective to reduce the blood sugar level of diabetic rats but also non-toxic for the animal body, in particular for sensitive organs like kidney, liver, heart, lung and spleen. These results indicate that PLGA nanospheres have a great potential for oral delivery of pioglitazone.
Keywords: pioglitazone; PLGA nanospheres; type 2 diabetes; drug delivery; controlled release
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Seen by:The Caffeine and Java Myth: The Relationship Between the World of Coffee to the Science of Diabetes and Obesity in Public Health
by Roy Chan
Key words: public health, medicine, coffee, diabetes, obesity, high blood pressure, caffine
In this new... more
Key words: public health, medicine, coffee, diabetes, obesity, high blood pressure, caffine
In this new century, a cup of coffee can hold many things – the long morning hours driving to the office to the long nights studying and cramming for exams in the library. Coffee, in our context today, has become extremely popular where now more than 65 countries across the world grows coffee and is currently the second most traded commodities in the world, first being oil. Steven Topik, currently Professor of History at the University of California Irvine, once state that coffee provides “a case study for the development of the world economy for the last 500 years” (Topik, 2009). Although coffee will continue to rise the global marketplace, to what extent are the public health and medical problems assicuated with drinking too much coffee and what are its risk factors.
This short paper possible solution that could help prevent individuals from acquiring diabetes, obesity, or inhibiting high blood pressure as a result from caffeinated drinks. Until there are more accurate studies that prove the relationship between coffee and diabetes, various prevention techniques, intervention programs and new methods for selling, trading and producing coffee will remain ineffective. Risk factors, such as diabetes, obesity, stroke, heart disease, and high blood pressure in relation to caffeinated drinks must be addressed in higher priority at both local schools and at the community level in order to prevent early diabetes and/or obesity.
Patients' perceptions and experiences of transitions in diabetes care: a longitudinal qualitative study
by David Rankin
Lawton J, Rankin D, Peel E, and Douglas M. (2009) Patients’ perceptions and experiences of transitions in diabetes care: A longitudinal qualitative study. Health Expectations, 12:138-148.
Objective To examine patients perceptions and experiences over
time of the devolvement of diabetes care ⁄... more
Objective To examine patients perceptions and experiences over
time of the devolvement of diabetes care ⁄ reviews from secondary to primary health-care settings.
Design Repeat in-depth interviews with 20 patients over 4 years.
Participants and setting Twenty type 2 diabetes patients recruited from primary- and secondary-care settings across Lothian, Scotland.
Results Patients views about their current diabetes care were informed by their previous service contact. The devolvement of diabetes care ⁄ reviews to general practice was presented as a mixed blessing. Patients gained reassurance from their perception that receiving practice-based care ⁄ reviews signified that their diabetes was well-controlled. However, they also expressed resentment that, by achieving good control, they received what they saw as inferior care and ⁄ or less-frequent reviews to others with poorer control. While patients tended to regard GPs as having adequate expertise to conduct their practice-based reviews, they were more ambivalent about nurses taking on this role. Opportunities to receive holistic care in general practice were not always realized due to patients seeing health-care professionals for diabetes management to whom they would not normally present for other health issues.
Conclusions It is important to educate patients about their care pathways, and to reassure them that frequency of reviews depends more on clinical need than location of care and that similar care guidelines are followed in hospital clinics and general practice. A patients history of service contact may need to be taken into account in future studies of service satisfaction.
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